Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.P153_G154del2

c.457_461del6

Surrounding Variants

9 papers

NM_000546.6

p.T155fs

c.463_464fs

23 papers

NM_000546.6

p.T155S

c.463A>T

25 papers

NM_000546.6

p.T155A

c.463A>G

69 papers

NM_000546.6

p.T155P

c.463A>C

1 paper

NM_000546.6

p.V147_G154ins2

c.439_462dup24

2 papers

NM_000546.6

p.G154delFs

c.462delG

1 paper

NM_000546.6

p.G154_T155Fs

c.461_463delinsCTFs

1 paper

NM_000546.6

p.G154_T155Fs

c.461_463delinsCCFs

2 papers

NM_000546.6

p.G154del1

c.460_462delGCC

1 paper

NM_000546.6

p.P153_G154delFs

c.458_462del5

1 paper

NM_000546.6

p.P152_G154del0

c.454_462del9

1 paper

NM_000546.6

p.L145_G154delFs

c.434_462del29