Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

188 papers

NM_000546.6

p.G154V

c.461G>T

Surrounding Variants

11 papers

NM_000546.6

p.G154A

c.461G>C

40 papers

NM_000546.6

p.G154D

c.461G>A

1 paper

NM_000546.6

p.G154delins

c.460_461delinsAT

1 paper

NM_000546.6

p.G154delins

c.460_461delinsAA

1 paper

NM_000546.6

p.P153_G154delFs

c.457_460del4

1 paper

NM_000546.6

p.P151_G154del0

c.452_460del9

2 papers

NM_000546.6

p.T150_G154delFs

c.450_460del11

9 papers

NM_000546.6

p.T150_G154delFs

c.448_460del13

1 paper

NM_000546.6

p.V147_P153del7

c.439_458del21

1 paper

NM_000546.6

p.Q144_G154delFs

c.430_460del31

13 papers

NM_000546.6

p.G154C

c.460G>T

1 paper

NM_000546.6

p.G154Fs

c.460delinsTTFs