Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.P153delFs

c.459delG

Surrounding Variants

13 papers

NM_000546.6

p.G154C

c.460G>T

1 paper

NM_000546.6

p.G154Fs

c.460delinsTTFs

2 papers

NM_000546.6

p.P153insFs

c.457dupC

1 paper

NM_000546.6

p.G154insFs

c.460_461ins5

1 paper

NM_000546.6

p.G154ins2

c.460_461ins6

14 papers

NM_000546.6

p.G154R

c.460G>C

100 papers

NM_000546.6

p.G154S

c.460G>A

1 paper

NM_000546.6

p.P153delFs

c.458_459delGG

7 papers

NM_000546.6

p.P153del1

c.457_458delGGG

2 papers

NM_000546.6

p.P152_P153delFs

c.455_459del5

1 paper

NM_000546.6

p.P152_P153del2

c.454_458del6

1 paper

NM_000546.6

p.P151_P153delFs

c.452_459del8