Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

18 papers

NM_000546.6

p.P153A

c.457C>G

Surrounding Variants

31 papers

NM_000546.6

p.P153S

c.457C>T

1 paper

NM_000546.6

p.P153_G154insA

c.457_461ins3

1 paper

NM_000546.6

p.P153insFs

c.457_458insA

10 papers

NM_000546.6

p.P153T

c.457C>A

1 paper

NM_000546.6

p.P152_P153delins

c.456_457delinsTG

3 papers

NM_000546.6

p.P152delFs

c.456delC

1 paper

NM_000546.6

p.W146_P152del7

c.436_455del21

49 papers

NM_000546.6

p.P153fs

c.457_458fs

39 papers

NM_000546.6

p.P151insFs

c.451_452insC

2 papers

NM_000546.6

p.P152insFs

c.454_455dupCC

68 papers

NM_000546.6

p.P152fs

c.454_455fs

1 paper

NM_000546.6

p.P152P

c.456G>C