Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

68 papers

NM_000546.6

p.P152fs

c.454_455fs

Surrounding Variants

39 papers

NM_000546.6

p.P151insFs

c.451_452insC

2 papers

NM_000546.6

p.P152insFs

c.454_455dupCC

1 paper

NM_000546.6

p.P152P

c.456G>C

6 papers

NM_000546.6

p.P152P

c.456G>A

3 papers

NM_000546.6

p.P152Fs

c.455_456delinsTFs

35 papers

NM_000546.6

p.P152delFs

c.455delG

2 papers

NM_000546.6

p.P152delFs

c.454_455delGG

2 papers

NM_000546.6

p.P151_P152del1

c.453_455delGGG

2 papers

NM_000546.6

p.T150_P152del0

c.450_455del6

1 paper

NM_000546.6

p.T150_P152delFs

c.448_455del8

1 paper

NM_000546.6

p.P142_P151del10

c.424_452del30

357 papers

NM_000546.6

p.P152L

c.455C>T

NM_001126115.2

p.P20L

c.59C>T