Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

33 papers

NM_000546.6

p.P152Q

c.455C>A

Surrounding Variants

357 papers

NM_000546.6

p.P152L

c.455C>T

NM_001126115.2

p.P20L

c.59C>T

36 papers

NM_000546.6

p.P152R

c.455C>G

3 papers

NM_000546.6

p.P152insFs

c.455_456insT

1 paper

NM_000546.6

p.P152insFs

c.454_455ins7

1 paper

NM_000546.6

p.P152insFs

c.455_456ins1

1 paper

NM_000546.6

p.P152delins

c.454_455delinsTT

1 paper

NM_000546.6

p.W146_P152delFs

c.438_454del17

1 paper

NM_000546.6

p.L145_P151del7

c.433_452del21

39 papers

NM_000546.6

p.P151insFs

c.451_452insC

2 papers

NM_000546.6

p.P152insFs

c.454_455dupCC

68 papers

NM_000546.6

p.P152fs

c.454_455fs

1 paper

NM_000546.6

p.P152P

c.456G>C