Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

43 papers

NM_000546.6

p.P152fs

c.454_455fs

Surrounding Variants

73 papers

NM_000546.6

p.P152S

c.454C>T

13 papers

NM_000546.6

p.P152A

c.454C>G

2 papers

NM_000546.6

p.P152insFs

c.454_455ins1

29 papers

NM_000546.6

p.P152T

c.454C>A

1 paper

NM_000546.6

p.P151_P152delins

c.453_454delinsTT

1 paper

NM_000546.6

p.T150_P152delins

c.450_454delinsTA

3 papers

NM_000546.6

p.T150_P151del0

c.448_453del6

1 paper

NM_000546.6

p.P142_P151delFs

c.426_453del28

357 papers

NM_000546.6

p.P152L

c.455C>T

NM_001126115.2

p.P20L

c.59C>T

3 papers

NM_000546.6

p.P151P

c.453C>T

36 papers

NM_000546.6

p.P152R

c.455C>G

1 paper

NM_000546.6

p.P151P

c.453C>G