Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_000546.6

p.P151fs

c.451_452fs

Surrounding Variants

3 papers

NM_000546.6

p.P151P

c.453C>T

1 paper

NM_000546.6

p.P151P

c.453C>G

1 paper

NM_000546.6

p.P151ins1

c.452_453insCGC

1 paper

NM_000546.6

p.L145_P151ins2

c.435_452dup18

2 papers

NM_000546.6

p.P151P

c.453C>A

1 paper

NM_000546.6

p.P151Fs

c.452_453delinsTFs

1 paper

NM_000546.6

p.P151delins

c.452_453delinsTT

1 paper

NM_000546.6

p.P151delins

c.452_453delinsAA

1 paper

NM_000546.6

p.T150_P151del1

c.450_452delGGT

1 paper

NM_000546.6

p.D148_P151del0

c.444_452del9

1 paper

NM_000546.6

p.D148_P151delFs

c.442_452del11

1 paper

NM_000546.6

p.V147_P151delFs

c.440_452del13