Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

92 papers

NM_000546.6

p.P151A

c.451C>G

Surrounding Variants

335 papers

NM_000546.6

p.P151S

c.451C>T

NM_001126115.2

p.P19S

c.55C>T

1 paper

NM_000546.6

p.P151insFs

c.451_452ins4

116 papers

NM_000546.6

p.P151T

c.451C>A

9 papers

NM_000546.6

p.P151fs

c.451_452fs

1 paper

NM_000546.6

p.T150del1

c.448_449delTGT

3 papers

NM_000546.6

p.S149_T150del2

c.445_449del6

30 papers

NM_000546.6

p.P151L

c.452C>T

106 papers

NM_000546.6

p.P151R

c.452C>G

NM_001126115.2

p.P19R

c.56C>G

137 papers

NM_000546.6

p.P151H

c.452C>A

NM_001126115.2

p.P19H

c.56C>A

2 papers

NM_000546.6

p.P151delins

c.451_452delinsTT

1 paper

NM_000546.6

p.T150_P151Fs

c.450_452delinsTFs

2 papers

NM_000546.6

p.T150_P151delFs

c.450_451delGT