Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

22 papers

NM_000546.6

p.D148E

c.444T>G

Surrounding Variants

1 paper

NM_000546.6

p.D148_S149insFs

c.444_445insG

1 paper

NM_000546.6

p.D148_S149insFs

c.444_445insC

4 papers

NM_000546.6

p.D148fs

c.442_443fs

2 papers

NM_000546.6

p.D148insFs

c.443dupA

1 paper

NM_000546.6

p.D148D

c.444T>C

22 papers

NM_000546.6

p.D148E

c.444T>A

1 paper

NM_000546.6

p.D148delFs

c.443delT

1 paper

NM_000546.6

p.D148delFs

c.442_443delTC

1 paper

NM_000546.6

p.D148delins

c.442_444delinsATG

1 paper

NM_000546.6

p.D148delins

c.442_444delinsTGG

1 paper

NM_000546.6

p.D148delins

c.442_444delinsTAG

2 papers

NM_000546.6

p.D148delins

c.442_444delinsTGA