Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.V147delFs

c.441delA

Surrounding Variants

8 papers

NM_000546.6

p.D148fs

c.442_443fs

24 papers

NM_000546.6

p.D148Y

c.442G>T

4 papers

NM_000546.6

p.V147insFs

c.440_441insT

1 paper

NM_000546.6

p.D148insFs

c.442_443insC

1 paper

NM_000546.6

p.D148_S149insA

c.442_446ins3

1 paper

NM_000546.6

p.D148ins5

c.442_443ins15

12 papers

NM_000546.6

p.D148H

c.442G>C

34 papers

NM_000546.6

p.D148N

c.442G>A

2 papers

NM_000546.6

p.V147delFs

c.440_441delAA

1 paper

NM_000546.6

p.L145_V147del3

c.433_440del9

1 paper

NM_000546.6

p.L145_D148Fs

c.433_442delinsAGAFs

1 paper

NM_000546.6

p.V147_D148insFs

c.441_442insC