Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.V147V

c.441T>C

Surrounding Variants

1 paper

NM_000546.6

p.V147_D148insFs

c.441_442insC

23 papers

NM_000546.6

p.V147fs

c.439_440fs

2 papers

NM_000546.6

p.V147_D148insFs

c.441_442insA

1 paper

NM_000546.6

p.V147V

c.441T>G

1 paper

NM_000546.6

p.V147V

c.441T>A

2 papers

NM_000546.6

p.V147delins

c.440_441delinsAG

1 paper

NM_000546.6

p.V147delFs

c.439_440delAC

1 paper

NM_000546.6

p.V147delins

c.439_441delinsATG

1 paper

NM_000546.6

p.V147delins

c.439_441delinsTGG

1 paper

NM_000546.6

p.V147delins

c.439_441delinsTAG

1 paper

NM_000546.6

p.V147delins

c.439_441delinsTGA

1 paper

NM_000546.6

p.V147delins

c.439_441delinsTAA