Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

238 papers

NM_000546.6

p.W146*

c.438G>A

NM_001126115.2

p.W14*

c.42G>A

Surrounding Variants

17 papers

NM_000546.6

p.W146C

c.438G>T

2 papers

NM_000546.6

p.W146_V147insFs

c.438_439insT

1 paper

NM_000546.6

p.W146_V147insFs

c.438_439insC

10 papers

NM_000546.6

p.W146fs

c.436_437fs

1 paper

NM_000546.6

p.W146_V147insFs

c.438_439insA

15 papers

NM_000546.6

p.W146C

c.438G>C

1 paper

NM_000546.6

p.W146delins

c.437_438delinsTC

1 paper

NM_000546.6

p.W146delins

c.437_438delinsAC

1 paper

NM_000546.6

p.W146delFs

c.436_437delCA

1 paper

NM_000546.6

p.W146delins

c.436_438delinsGAC

1 paper

NM_000546.6

p.W146delins

c.436_438delinsCAC

1 paper

NM_000546.6

p.W146delins

c.436_438delinsAAC