Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.L145delins

c.433_434delinsGC

Surrounding Variants

1 paper

NM_000546.6

p.L145insFs

c.433dupC

1 paper

NM_000546.6

p.V143_L145insFs

c.429_433dup5

1 paper

NM_000546.6

p.L145insFs

c.434_435insA

76 papers

NM_000546.6

p.L145R

c.434T>G

NM_001126115.2

p.L13R

c.38T>G

73 papers

NM_000546.6

p.L145P

c.434T>C

70 papers

NM_000546.6

p.L145Q

c.434T>A

2 papers

NM_000546.6

p.L145delFs

c.433delG

1 paper

NM_000546.6

p.L145delins

c.433_434delinsTG

1 paper

NM_000546.6

p.L145delins

c.433_434delinsGG

1 paper

NM_000546.6

p.L145delins

c.433_434delinsTC

1 paper

NM_000546.6

p.L145delins

c.433_434delinsAC

1 paper

NM_000546.6

p.L145delins

c.433_434delinsTA