Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.Q144insFs

c.431_432insGC

Surrounding Variants

18 papers

NM_000546.6

p.Q144L

c.431A>T

22 papers

NM_000546.6

p.Q144R

c.431A>G

42 papers

NM_000546.6

p.Q144P

c.431A>C

1 paper

NM_000546.6

p.Q144insFs

c.431_432insT

1 paper

NM_000546.6

p.Q144insFs

c.431_432insC

1 paper

NM_000546.6

p.Q144delins

c.430_431delinsGT

1 paper

NM_000546.6

p.Q144delins

c.430_431delinsAT

1 paper

NM_000546.6

p.Q144delins

c.430_431delinsGG

1 paper

NM_000546.6

p.Q144delins

c.430_431delinsTC

1 paper

NM_000546.6

p.Q144delins

c.430_431delinsGC

1 paper

NM_000546.6

p.Q144delins

c.430_431delinsAC

1 paper

NM_000546.6

p.Q144delFs

c.430delG