Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.Q144E

c.430C>G

Surrounding Variants

10 papers

NM_000546.6

p.Q144fs

c.430_431fs

117 papers

NM_000546.6

p.Q144*

c.430C>T

1 paper

NM_000546.6

p.Q144Fs

c.430delinsTTFs

1 paper

NM_000546.6

p.Q144insFs

c.430_431insT

1 paper

NM_000546.6

p.V143insFs

c.429dupG

1 paper

NM_000546.6

p.V143insFs

c.428_429dupTG

1 paper

NM_000546.6

p.Q144_L145ins5

c.430_434ins15

10 papers

NM_000546.6

p.Q144K

c.430C>A

2 papers

NM_000546.6

p.V143_Q144delins

c.429_430delinsTT

1 paper

NM_000546.6

p.V143delFs

c.429delC

2 papers

NM_000546.6

p.V143delFs

c.428_429delCA

1 paper

NM_000546.6

p.V143del1

c.427_428delCAC