Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_000546.6

p.P142del1

c.424_425delAGG

Surrounding Variants

23 papers

NM_000546.6

p.V143L

c.427G>T

1 paper

NM_000546.6

p.P142insFs

c.426dupT

1 paper

NM_000546.6

p.V143insFs

c.427_428insC

2 papers

NM_000546.6

p.V143insFs

c.427_428insA

22 papers

NM_000546.6

p.V143L

c.427G>C

NM_001126115.2

p.V11L

c.31G>C

193 papers

NM_000546.6

p.V143M

c.427G>A

1 paper

NM_000546.6

p.P142_V143delins

c.426_427delinsAT

2 papers

NM_000546.6

p.P142delFs

c.426delA

14 papers

NM_000546.6

p.V143fs

c.427_428fs

2 papers

NM_000546.6

p.P142delFs

c.425_426delAG

2 papers

NM_000546.6

p.T140_P142delFs

c.420_426del7

9 papers

NM_000546.6

p.L130_P142delFs

c.390_426del37