Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.P142delins

c.424_425delinsTT

Surrounding Variants

36 papers

NM_000546.6

p.P142L

c.425C>T

9 papers

NM_000546.6

p.P142R

c.425C>G

1 paper

NM_000546.6

p.P142insFs

c.425_426insG

1 paper

NM_000546.6

p.P142insFs

c.425_426insA

14 papers

NM_000546.6

p.P142H

c.425C>A

1 paper

NM_000546.6

p.P142delins

c.424_425delinsGT

1 paper

NM_000546.6

p.P142delins

c.424_425delinsAT

1 paper

NM_000546.6

p.P142delins

c.424_425delinsTG

1 paper

NM_000546.6

p.P142delins

c.424_425delinsTA

1 paper

NM_000546.6

p.P142delins

c.424_425delinsGA

1 paper

NM_000546.6

p.P142delins

c.424_425delinsAA

1 paper

NM_000546.6

p.C141_P142del1

c.422_424delGGC