Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_000546.6

p.C141fs

c.421_422fs

Surrounding Variants

2 papers

NM_000546.6

p.C141C

c.423C>T

91 papers

NM_000546.6

p.C141W

c.423C>G

1 paper

NM_000546.6

p.C141_P142insFs

c.423_424insT

5 papers

NM_000546.6

p.C141insFs

c.422dupG

1 paper

NM_000546.6

p.C141_P142insFs

c.423_424insA

24 papers

NM_000546.6

p.C141*

c.423C>A

1 paper

NM_000546.6

p.C141delins

c.422_423delinsAG

1 paper

NM_000546.6

p.C141delFs

c.422delC

1 paper

NM_000546.6

p.C141delins

c.422_423delinsAA

1 paper

NM_000546.6

p.C141delins

c.421_423delinsATG

1 paper

NM_000546.6

p.C141delFs

c.421_422delCA

1 paper

NM_000546.6

p.C141delins

c.421_423delinsGAA