Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

13 papers

NM_000546.6

p.A138G

c.413C>G

Surrounding Variants

181 papers

NM_000546.6

p.A138V

c.413C>T

1 paper

NM_000546.6

p.A138insFs

c.413_414insT

1 paper

NM_000546.6

p.A138insFs

c.413_414insG

1 paper

NM_000546.6

p.A138insFs

c.413_414insA

17 papers

NM_000546.6

p.A138D

c.413C>A

1 paper

NM_000546.6

p.A138delins

c.412_413delinsTT

1 paper

NM_000546.6

p.A138delins

c.412_413delinsCT

1 paper

NM_000546.6

p.A138delins

c.412_413delinsAT

1 paper

NM_000546.6

p.A138delins

c.412_413delinsTG

1 paper

NM_000546.6

p.A138delins

c.412_413delinsCG

2 papers

NM_000546.6

p.L137delFs

c.411delC

1 paper

NM_000546.6

p.A138delins

c.412_413delinsTA