Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.L137delins

c.409_410delinsAC

Surrounding Variants

3 papers

NM_000546.6

p.L137insFs

c.409dupC

1 paper

NM_000546.6

p.L137insFs

c.410_411insA

11 papers

NM_000546.6

p.L137R

c.410T>G

12 papers

NM_000546.6

p.L137P

c.410T>C

37 papers

NM_000546.6

p.L137Q

c.410T>A

2 papers

NM_000546.6

p.L137delFs

c.409delG

1 paper

NM_000546.6

p.L137delins

c.409_410delinsTG

1 paper

NM_000546.6

p.L137delins

c.409_410delinsGG

1 paper

NM_000546.6

p.L137delins

c.409_410delinsTC

1 paper

NM_000546.6

p.L137delins

c.409_410delinsGC

1 paper

NM_000546.6

p.L137delins

c.409_410delinsTA

1 paper

NM_000546.6

p.L137delins

c.409_410delinsGA