Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

156 papers

NM_000546.6

p.Q136*

c.406C>T

Surrounding Variants

74 papers

NM_000546.6

p.Q136E

c.406C>G

2 papers

NM_000546.6

p.Q136insFs

c.406_407insT

1 paper

NM_000546.6

p.Q136insFs

c.406_407insG

1 paper

NM_000546.6

p.Q136insFs

c.406_407ins1

1 paper

NM_000546.6

p.Q136ins1

c.406_407insTCA

10 papers

NM_000546.6

p.Q136K

c.406C>A

2 papers

NM_000546.6

p.C135_Q136delins

c.405_406delinsTT

1 paper

NM_000546.6

p.C135delFs

c.404_405delGC

1 paper

NM_000546.6

p.C135_Q136delins

c.404_406delinsCCA

1 paper

NM_000546.6

p.C135del1

c.403_404delGCA

9 papers

NM_000546.6

p.Q136fs

c.406_407fs

5 papers

NM_000546.6

p.C135C

c.405C>T