Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.M133_C135ins1

c.399_404dup6

Surrounding Variants

5 papers

NM_000546.6

p.C135C

c.405C>T

108 papers

NM_000546.6

p.C135W

c.405C>G

NM_001126115.2

p.C3W

c.9C>G

1 paper

NM_000546.6

p.C135_Q136insFs

c.405_406insT

1 paper

NM_000546.6

p.C135insFs

c.404dupG

42 papers

NM_000546.6

p.C135fs

c.403_404fs

1 paper

NM_000546.6

p.C135_Q136insFs

c.405_406insA

1 paper

NM_000546.6

p.C135_Q136ins1

c.405_406insTCA

35 papers

NM_000546.6

p.C135*

c.405C>A

2 papers

NM_000546.6

p.C135delins

c.404_405delinsTT

1 paper

NM_000546.6

p.C135delins

c.404_405delinsAG

4 papers

NM_000546.6

p.C135delFs

c.404delC

1 paper

NM_000546.6

p.C135delins

c.404_405delinsAA