Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.C135delins

c.403_404delinsAC

Surrounding Variants

255 papers

NM_000546.6

p.C135F

c.404G>T

5 papers

NM_000546.6

p.F134_C135insFs

c.402_403insT

1 paper

NM_000546.6

p.F134insFs

c.400_401insTT

2 papers

NM_000546.6

p.C135insFs

c.404_405insA

67 papers

NM_000546.6

p.C135S

c.404G>C

302 papers

NM_000546.6

p.C135Y

c.404G>A

1 paper

NM_000546.6

p.C135delins

c.403_404delinsGT

1 paper

NM_000546.6

p.C135delins

c.403_404delinsCT

1 paper

NM_000546.6

p.C135delins

c.403_404delinsAT

24 papers

NM_000546.6

p.C135delFs

c.403delA

1 paper

NM_000546.6

p.C135delins

c.403_404delinsGC

1 paper

NM_000546.6

p.C135delins

c.403_404delinsCC