Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

23 papers

NM_000546.6

p.C135fs

c.403_404fs

Surrounding Variants

1 paper

NM_000546.6

p.C135insFs

c.403_404insC

1 paper

NM_000546.6

p.C135_Q136insGA

c.403_407ins6

2 papers

NM_000546.6

p.C135insFs

c.403_404insA

1 paper

NM_000546.6

p.C135insFs

c.403_404ins4

39 papers

NM_000546.6

p.C135G

c.403T>G

102 papers

NM_000546.6

p.C135R

c.403T>C

NM_001126115.2

p.C3R

c.7T>C

62 papers

NM_000546.6

p.C135S

c.403T>A

1 paper

NM_000546.6

p.M133_F134del2

c.397_401del6

2 papers

NM_000546.6

p.K132_F134del0

c.394_402del9

1 paper

NM_000546.6

p.N131_F134del4

c.391_401del12

1 paper

NM_000546.6

p.F134_C135insFs

c.402_403insG

1 paper

NM_000546.6

p.F134_C135insFs

c.402_403insC