Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_000546.6

p.F134fs

c.400_401fs

Surrounding Variants

1 paper

NM_000546.6

p.F134_C135insFs

c.402_403insG

1 paper

NM_000546.6

p.F134_C135insFs

c.402_403insC

1 paper

NM_000546.6

p.F134_C135insFs

c.402_403insA

158 papers

NM_000546.6

p.F134L

c.402T>G

4 papers

NM_000546.6

p.F134F

c.402T>C

157 papers

NM_000546.6

p.F134L

c.402T>A

1 paper

NM_000546.6

p.F134delins

c.401_402delinsGG

1 paper

NM_000546.6

p.F134delins

c.401_402delinsAG

1 paper

NM_000546.6

p.F134delins

c.401_402delinsGA

1 paper

NM_000546.6

p.F134delins

c.400_402delinsATG

1 paper

NM_000546.6

p.F134delins

c.400_402delinsGAA

1 paper

NM_000546.6

p.F134delins

c.400_402delinsCAA