Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.F134delins

c.400_401delinsAC

Surrounding Variants

1 paper

NM_000546.6

p.M133_F134insFs

c.399_400dupGT

2 papers

NM_000546.6

p.F134insFs

c.401_402insG

1 paper

NM_000546.6

p.F134insFs

c.401_402insC

1 paper

NM_000546.6

p.F134insFs

c.401_402insA

64 papers

NM_000546.6

p.F134C

c.401T>G

46 papers

NM_000546.6

p.F134S

c.401T>C

14 papers

NM_000546.6

p.F134Y

c.401T>A

1 paper

NM_000546.6

p.F134delins

c.400_401delinsGG

1 paper

NM_000546.6

p.F134delins

c.400_401delinsCG

1 paper

NM_000546.6

p.F134delins

c.400_401delinsGC

1 paper

NM_000546.6

p.F134delins

c.400_401delinsCC

1 paper

NM_000546.6

p.F134delins

c.400_401delinsGA