Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.F134insFs

c.400_401insA

Surrounding Variants

3 papers

NM_000546.6

p.M133insFs

c.399dupG

1 paper

NM_000546.6

p.F134insFs

c.400_401insC

3 papers

NM_000546.6

p.F134_C135insT

c.400_404ins3

53 papers

NM_000546.6

p.F134V

c.400T>G

158 papers

NM_000546.6

p.F134L

c.400T>C

25 papers

NM_000546.6

p.F134I

c.400T>A

7 papers

NM_000546.6

p.F134fs

c.400_401fs

1 paper

NM_000546.6

p.M133delFs

c.399delC

2 papers

NM_000546.6

p.M133del1

c.397_398delCAT

1 paper

NM_000546.6

p.N131_M133delFs

c.393_399del7

1 paper

NM_000546.6

p.N131_M133del0

c.391_399del9

1 paper

NM_000546.6

p.L130_M133del4

c.388_398del12