Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.M133delins

c.397_398delinsGC

Surrounding Variants

1 paper

NM_000546.6

p.M133insFs

c.398_399insG

1 paper

NM_000546.6

p.M133insFs

c.398_399insC

2 papers

NM_000546.6

p.M133insFs

c.398_399insA

1 paper

NM_000546.6

p.M133insFs

c.397_398ins5

31 papers

NM_000546.6

p.M133R

c.398T>G

63 papers

NM_000546.6

p.M133T

c.398T>C

75 papers

NM_000546.6

p.M133K

c.398T>A

4 papers

NM_000546.6

p.M133delFs

c.397delT

1 paper

NM_000546.6

p.M133delins

c.397_398delinsTG

1 paper

NM_000546.6

p.M133delins

c.397_398delinsGG

1 paper

NM_000546.6

p.M133delins

c.397_398delinsCC

1 paper

NM_000546.6

p.M133delins

c.397_398delinsTA