Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

88 papers

NM_000546.6

p.M133L

c.397A>T

Surrounding Variants

8 papers

NM_000546.6

p.M133fs

c.397_398fs

17 papers

NM_000546.6

p.M133V

c.397A>G

86 papers

NM_000546.6

p.M133L

c.397A>C

1 paper

NM_000546.6

p.M133insFs

c.397_398insG

1 paper

NM_000546.6

p.P128_K132insFs

c.383_396dup14

1 paper

NM_000546.6

p.M133insFs

c.397_398insC

1 paper

NM_000546.6

p.K132_M133delins

c.396_397delinsTT

1 paper

NM_000546.6

p.K132delFs

c.396delC

1 paper

NM_000546.6

p.A129_K132delFs

c.387_396del10

4 papers

NM_000546.6

p.Y126_K132del0

c.376_396del21

1 paper

NM_000546.6

p.M133insFs

c.398_399insG

1 paper

NM_000546.6

p.M133insFs

c.398_399insC