Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.K132delFs

c.395delT

Surrounding Variants

243 papers

NM_000546.6

p.K132N

c.396G>T

1 paper

NM_000546.6

p.K132_M133insFs

c.396_397insT

1 paper

NM_000546.6

p.K132_M133insFs

c.396_397insC

6 papers

NM_000546.6

p.K132fs

c.394_395fs

2 papers

NM_000546.6

p.K132insFs

c.394dupA

1 paper

NM_000546.6

p.N131_K132ins0

c.393_395dupCAA

243 papers

NM_000546.6

p.K132N

c.396G>C

3 papers

NM_000546.6

p.K132K

c.396G>A

1 paper

NM_000546.6

p.K132delins

c.395_396delinsGC

1 paper

NM_000546.6

p.K132delins

c.395_396delinsTA

1 paper

NM_000546.6

p.K132delFs

c.394_395delTT

1 paper

NM_000546.6

p.K132delins

c.394_396delinsTTC