Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.K132delins

c.394_395delinsCC

Surrounding Variants

73 papers

NM_000546.6

p.K132M

c.395A>T

295 papers

NM_000546.6

p.K132R

c.395A>G

53 papers

NM_000546.6

p.K132T

c.395A>C

1 paper

NM_000546.6

p.K132insFs

c.395_396insT

1 paper

NM_000546.6

p.K132insFs

c.395_396insC

1 paper

NM_000546.6

p.K132ins1

c.395_396ins3

1 paper

NM_000546.6

p.A129_K132ins1

c.386_394dup9

1 paper

NM_000546.6

p.K132delins

c.394_395delinsGT

1 paper

NM_000546.6

p.K132delins

c.394_395delinsCT

2 papers

NM_000546.6

p.K132delins

c.394_395delinsTG

1 paper

NM_000546.6

p.K132delins

c.394_395delinsGG

1 paper

NM_000546.6

p.K132delins

c.394_395delinsGC