Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.K132insFs

c.394_395insT

Surrounding Variants

7 papers

NM_000546.6

p.K132fs

c.394_395fs

22 papers

NM_000546.6

p.K132*

c.394A>T

145 papers

NM_000546.6

p.K132E

c.394A>G

78 papers

NM_000546.6

p.K132Q

c.394A>C

1 paper

NM_000546.6

p.K132insFs

c.394_395insG

2 papers

NM_000546.6

p.N131_K132insFs

c.393_394insC

4 papers

NM_000546.6

p.N131delFs

c.393delG

1 paper

NM_000546.6

p.P128_N131delFs

c.384_393del10

1 paper

NM_000546.6

p.S127_N131del5

c.379_392del15

3 papers

NM_000546.6

p.N131N

c.393C>T

23 papers

NM_000546.6

p.N131K

c.393C>G

1 paper

NM_000546.6

p.N131_K132insFs

c.393_394insT