Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.N131delins

c.392_393delinsTG

Surrounding Variants

3 papers

NM_000546.6

p.N131N

c.393C>T

23 papers

NM_000546.6

p.N131K

c.393C>G

1 paper

NM_000546.6

p.N131_K132insFs

c.393_394insT

1 paper

NM_000546.6

p.N131_K132insFs

c.393_394insG

15 papers

NM_000546.6

p.N131fs

c.391_392fs

2 papers

NM_000546.6

p.N131insFs

c.392dupA

1 paper

NM_000546.6

p.A129_N131insFs

c.385_392dup8

24 papers

NM_000546.6

p.N131K

c.393C>A

4 papers

NM_000546.6

p.N131delFs

c.391delT

1 paper

NM_000546.6

p.N131delins

c.392_393delinsGA

1 paper

NM_000546.6

p.N131delins

c.391_393delinsTGG

1 paper

NM_000546.6

p.N131delins

c.391_393delinsTAG