Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.N131delins

c.391_392delinsTG

Surrounding Variants

77 papers

NM_000546.6

p.N131I

c.392A>T

45 papers

NM_000546.6

p.N131S

c.392A>G

12 papers

NM_000546.6

p.N131T

c.392A>C

1 paper

NM_000546.6

p.N131insFs

c.392_393insT

1 paper

NM_000546.6

p.N131insFs

c.392_393insG

1 paper

NM_000546.6

p.N131delins

c.391_392delinsGT

1 paper

NM_000546.6

p.N131delins

c.391_392delinsCT

1 paper

NM_000546.6

p.N131delins

c.391_392delinsGG

1 paper

NM_000546.6

p.N131delins

c.391_392delinsGC

1 paper

NM_000546.6

p.N131delins

c.391_392delinsCC

2 papers

NM_000546.6

p.L130_N131delFs

c.390_391delTG

1 paper

NM_000546.6

p.L130_N131del1

c.389_391delTGA