Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

14 papers

NM_000546.6

p.N131H

c.391A>C

Surrounding Variants

15 papers

NM_000546.6

p.N131fs

c.391_392fs

52 papers

NM_000546.6

p.N131Y

c.391A>T

11 papers

NM_000546.6

p.N131D

c.391A>G

1 paper

NM_000546.6

p.N131insFs

c.391_392insT

1 paper

NM_000546.6

p.N131insFs

c.391_392insG

2 papers

NM_000546.6

p.N131insFs

c.391_392insC

1 paper

NM_000546.6

p.N131_K132insA

c.391_395ins3

1 paper

NM_000546.6

p.N131insFs

c.391_392ins4

1 paper

NM_000546.6

p.L130delFs

c.390delG

1 paper

NM_000546.6

p.L130delFs

c.389_390delGA

4 papers

NM_000546.6

p.L130del1

c.388_389delGAG

1 paper

NM_000546.6

p.A129_L130delFs

c.387_390del4