Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.L130insFs

c.388_389insG

Surrounding Variants

108 papers

NM_000546.6

p.L130F

c.388C>T

133 papers

NM_000546.6

p.L130V

c.388C>G

1 paper

NM_000546.6

p.P128_A129insFs

c.384_387dup4

1 paper

NM_000546.6

p.L130insFs

c.388_389insA

19 papers

NM_000546.6

p.L130I

c.388C>A

11 papers

NM_000546.6

p.L130fs

c.388_389fs

4 papers

NM_000546.6

p.A129del1

c.385_387delGGC

1 paper

NM_000546.6

p.P128_A129delFs

c.384_387del4

1 paper

NM_000546.6

p.L130insFs

c.389_390insG

4 papers

NM_000546.6

p.L130insFs

c.388dupC

1 paper

NM_000546.6

p.A129_L130insFs

c.387_388dupCC

1 paper

NM_000546.6

p.L130insFs

c.389_390insA