Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S127delins

c.379_380delinsCG

Surrounding Variants

285 papers

NM_000546.6

p.S127F

c.380C>T

22 papers

NM_000546.6

p.S127C

c.380C>G

1 paper

NM_000546.6

p.S127insFs

c.379dupT

1 paper

NM_000546.6

p.Y126_S127ins0

c.377_379dupACT

1 paper

NM_000546.6

p.S127insFs

c.380_381insG

1 paper

NM_000546.6

p.S127insFs

c.380_381insA

1 paper

NM_000546.6

p.S127insFs

c.380_381insTA

94 papers

NM_000546.6

p.S127Y

c.380C>A

1 paper

NM_000546.6

p.S127delins

c.379_380delinsGT

1 paper

NM_000546.6

p.S127delins

c.379_380delinsCT

1 paper

NM_000546.6

p.S127delins

c.379_380delinsAT

1 paper

NM_000546.6

p.S127delins

c.379_380delinsGG