Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

39 papers

NM_000546.6

p.S127T

c.379T>A

Surrounding Variants

1 paper

NM_000546.6

p.S127insFs

c.379_380insG

1 paper

NM_000546.6

p.Y126insFs

c.378dupC

1 paper

NM_000546.6

p.S127insFs

c.379_380insA

9 papers

NM_000546.6

p.S127A

c.379T>G

65 papers

NM_000546.6

p.S127P

c.379T>C

2 papers

NM_000546.6

p.Y126delFs

c.378delG

3 papers

NM_000546.6

p.Y126delFs

c.377_378delGT

1 paper

NM_000546.6

p.Y126_S127delins

c.377_379delinsGCC

4 papers

NM_000546.6

p.S127fs

c.379_380fs

285 papers

NM_000546.6

p.S127F

c.380C>T

5 papers

NM_000546.6

p.Y126Y

c.378C>T

73 papers

NM_000546.6

p.Y126*

c.378C>G