Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.T125_Y126Splc

c.376-4A>T

Surrounding Variants

1 paper

NM_000546.6

p.T125_Y126Splc

c.376-4A>G

1 paper

NM_000546.6

p.T125_Y126Splc

c.376-4A>C

1 paper

NM_000546.6

p.T125_Y126Splc

c.376-5T>G

1 paper

NM_000546.6

p.T125_Y126Splc

c.376-5T>C

1 paper

NM_000546.6

p.T125_Y126Splc

c.376-5T>A

3 papers

NM_000546.6

p.T125_Y126Splc

c.376-3C>T

4 papers

NM_000546.6

p.T125_Y126Splc

c.376-3C>G

2 papers

NM_000546.6

p.T125_Y126Splc

c.376-3C>A

1 paper

NM_000546.6

p.T125_Y126Splc

c.376-6C>T

1 paper

NM_000546.6

p.T125_Y126Splc

c.376-6C>G

2 papers

NM_000546.6

p.T125_Y126Splc

c.376-6C>A

26 papers

NM_000546.6

p.T125_Y126Splc

c.376-2A>T