Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T125_Y126ins1

c.375_376insGTC

Surrounding Variants

43 papers

NM_000546.6

p.T125_Y126Splc

c.375+1G>T

1 paper

NM_000546.6

p.T125insFs

c.374_375dupCG

1 paper

NM_000546.6

p.C124_T125insFs

c.372_375dup4

14 papers

NM_000546.6

p.T125_Y126Splc

c.375+1G>C

79 papers

NM_000546.6

p.T125_Y126Splc

c.375+1G>A

NM_001276760.3

p.T86_Y87Splc

c.258+1G>A

2 papers

NM_000546.6

p.T125delFs

c.374_375delCG

2 papers

NM_000546.6

p.T125del1

c.373_374delCGT

2 papers

NM_000546.6

p.C124_T125delFs

c.372_375del4

2 papers

NM_000546.6

p.C124_T125del2

c.370_374del6

1 paper

NM_000546.6

p.T123_T125del3

c.367_374del9

1 paper

NM_000546.6

p.H115_T125delFs

c.345_375del31

1 paper

NM_000546.6

p.T125insFs

c.375dupG