Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T125delins

c.374_375delinsTT

Surrounding Variants

73 papers

NM_000546.6

p.T125T

c.375G>T

1 paper

NM_000546.6

p.T125insFs

c.374_375ins4

2 papers

NM_000546.6

p.T125Fs

c.375delinsTGCACGFs

5 papers

NM_000546.6

p.T125fs

c.373_374fs

1 paper

NM_000546.6

p.T125_Y126insFs

c.375_376ins37

1 paper

NM_000546.6

p.T125_Y126insFs

c.375_376insAA

31 papers

NM_000546.6

p.T125T

c.375G>C

155 papers

NM_000546.6

p.T125T

c.375G>A

NM_001126118.2

p.T86T

c.258G>A

1 paper

NM_000546.6

p.T125delFs

c.374delG

1 paper

NM_000546.6

p.T123_C124del2

c.367_371del6

1 paper

NM_000546.6

p.T123_T125delFs

c.368_374del7

1 paper

NM_000546.6

p.T118_C124del0

c.352_372del21