Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.T125insFs

c.373_374insA

Surrounding Variants

146 papers

NM_000546.6

p.T125M

c.374C>T

71 papers

NM_000546.6

p.T125R

c.374C>G

1 paper

NM_000546.6

p.T125ins2

c.374_375ins6

41 papers

NM_000546.6

p.T125K

c.374C>A

1 paper

NM_000546.6

p.T125delFs

c.373delT

1 paper

NM_000546.6

p.T123_T125Fs

c.369_375delinsGGFs

1 paper

NM_000546.6

p.G117_T125delFs

c.349_373del25

73 papers

NM_000546.6

p.T125T

c.375G>T

1 paper

NM_000546.6

p.T125insFs

c.374_375ins4

2 papers

NM_000546.6

p.T125Fs

c.375delinsTGCACGFs

5 papers

NM_000546.6

p.T125fs

c.373_374fs

1 paper

NM_000546.6

p.T125_Y126insFs

c.375_376ins37