Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.T123_C124delFs

c.369_370delAA

Surrounding Variants

10 papers

NM_000546.6

p.C124F

c.371G>T

2 papers

NM_000546.6

p.C124insFs

c.370dupT

1 paper

NM_000546.6

p.C124ins2

c.370_371ins6

1 paper

NM_000546.6

p.C124insFs

c.371_372insC

33 papers

NM_000546.6

p.C124S

c.371G>C

14 papers

NM_000546.6

p.C124Y

c.371G>A

8 papers

NM_000546.6

p.C124delFs

c.370delA

1 paper

NM_000546.6

p.T123_C124del1

c.368_370delAAG

1 paper

NM_000546.6

p.V122_C124del0

c.365_370del6

1 paper

NM_000546.6

p.K120_C124delFs

c.358_370del13

1 paper

NM_000546.6

p.K120_T123insFs

c.360_369dup10

1 paper

NM_000546.6

p.C124insFs

c.370_371insG