Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

41 papers

NM_000546.6

p.C124R

c.370T>C

Surrounding Variants

1 paper

NM_000546.6

p.K120_T123insFs

c.360_369dup10

1 paper

NM_000546.6

p.C124insFs

c.370_371insG

1 paper

NM_000546.6

p.C124insFs

c.370_371ins10

19 papers

NM_000546.6

p.C124G

c.370T>G

34 papers

NM_000546.6

p.C124S

c.370T>A

1 paper

NM_000546.6

p.T123_C124delins

c.369_370delinsGG

1 paper

NM_000546.6

p.T123delFs

c.368_369delAG

28 papers

NM_000546.6

p.C124fs

c.370_371fs

1 paper

NM_000546.6

p.V122_T123insFs

c.364_368dup5

6 papers

NM_000546.6

p.T123fs

c.367_368fs

1 paper

NM_000546.6

p.T123T

c.369T>G

1 paper

NM_000546.6

p.T123T

c.369T>C