Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.T123P

c.367A>C

Surrounding Variants

9 papers

NM_000546.6

p.T123fs

c.367_368fs

10 papers

NM_000546.6

p.T123S

c.367A>T

39 papers

NM_000546.6

p.T123A

c.367A>G

2 papers

NM_000546.6

p.V122insFs

c.366dupG

1 paper

NM_000546.6

p.V122delFs

c.366delC

53 papers

NM_000546.6

p.V122delFs

c.365_366delCA

2 papers

NM_000546.6

p.V122del1

c.364_365delCAC

1 paper

NM_000546.6

p.S121_V122del2

c.361_365del6

1 paper

NM_000546.6

p.A119_V122del4

c.355_365del12

1 paper

NM_000546.6

p.F113_V122del10

c.337_365del30

1 paper

NM_000546.6

p.G112_V122del11

c.334_365del33

3 papers

NM_000546.6

p.V122V

c.366G>T