Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_000546.6

p.V122V

c.366G>A

Surrounding Variants

3 papers

NM_000546.6

p.V122V

c.366G>T

2 papers

NM_000546.6

p.L111_V122insFs

c.331_365dup35

39 papers

NM_000546.6

p.V122fs

c.364_365fs

1 paper

NM_000546.6

p.S121_V122delFs

c.362_365del4

1 paper

NM_000546.6

p.S121_V122Fs

c.362_366delinsAFs

12 papers

NM_000546.6

p.V122G

c.365T>G

17 papers

NM_000546.6

p.V122A

c.365T>C

9 papers

NM_000546.6

p.V122E

c.365T>A

1 paper

NM_000546.6

p.T118_V122delFs

c.352_364del13

9 papers

NM_000546.6

p.T123fs

c.367_368fs

10 papers

NM_000546.6

p.T123S

c.367A>T

39 papers

NM_000546.6

p.T123A

c.367A>G