Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

12 papers

NM_000546.6

p.V122G

c.365T>G

Surrounding Variants

17 papers

NM_000546.6

p.V122A

c.365T>C

9 papers

NM_000546.6

p.V122E

c.365T>A

1 paper

NM_000546.6

p.T118_V122delFs

c.352_364del13

11 papers

NM_000546.6

p.V122L

c.364G>T

3 papers

NM_000546.6

p.V122V

c.366G>T

4 papers

NM_000546.6

p.S121insFs

c.363dupT

2 papers

NM_000546.6

p.L111_V122insFs

c.331_365dup35

39 papers

NM_000546.6

p.V122fs

c.364_365fs

8 papers

NM_000546.6

p.V122L

c.364G>C

18 papers

NM_000546.6

p.V122M

c.364G>A

3 papers

NM_000546.6

p.V122V

c.366G>A

2 papers

NM_000546.6

p.S121delFs

c.363delA