Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000546.6

p.S121S

c.363T>C

Surrounding Variants

7 papers

NM_000546.6

p.S121fs

c.361_362fs

1 paper

NM_000546.6

p.S121S

c.363T>G

1 paper

NM_000546.6

p.S121S

c.363T>A

1 paper

NM_000546.6

p.S121delFs

c.362delG

1 paper

NM_000546.6

p.K120_S121del1

c.360_362delGAC

1 paper

NM_000546.6

p.K120_S121delFs

c.358_362del5

11 papers

NM_000546.6

p.V122L

c.364G>T

4 papers

NM_000546.6

p.S121insFs

c.363dupT

8 papers

NM_000546.6

p.V122L

c.364G>C

18 papers

NM_000546.6

p.V122M

c.364G>A

2 papers

NM_000546.6

p.S121delFs

c.363delA

36 papers

NM_000546.6

p.V122fs

c.364_365fs