Varaico: Literature-Extracted Genetic Variants

TP53

19,071 papers

RefSeq Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expr...

Pfam Domains

P53_TADaa 6–30UCSCP53 transactivation motif

TAD2aa 35–59UCSCTransactivation domain 2

P53aa 99–289UCSCP53 DNA-binding domain

P53_tetrameraa 319–358UCSCP53 tetramerisation motif

Gene Aliases

HGNC Name

tumor protein p53

HGNC Alias Symbols

p53; LFS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000546.6

p.S121delFs

c.361delA

Surrounding Variants

38 papers

NM_000546.6

p.S121F

c.362C>T

6 papers

NM_000546.6

p.S121C

c.362C>G

1 paper

NM_000546.6

p.S121insFs

c.361_362insT

13 papers

NM_000546.6

p.S121Y

c.362C>A

1 paper

NM_000546.6

p.S116_S121delFs

c.348_361del14

1 paper

NM_000546.6

p.L114_K120del7

c.340_359del21

7 papers

NM_000546.6

p.S121fs

c.361_362fs

8 papers

NM_000546.6

p.S121A

c.361T>G

1 paper

NM_000546.6

p.S121S

c.363T>G

9 papers

NM_000546.6

p.S121P

c.361T>C

2 papers

NM_000546.6

p.S121S

c.363T>C

8 papers

NM_000546.6

p.S121T

c.361T>A